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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80648dd6059ff224115f582d4444a31fd732d8db2f2d3bd6de5baeaa5347867b' 
  AND token = '5MOtL7YsUZ3oxNB86JRRz4CMy3ZkI+fiF46m35zclZ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}