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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c4777f1024c11d1e44b7bdf99ce3e8f180c7a4375ed9f0cb94a7c82adff17e50' 
  AND token = 'gAPBAMZZpQ4N1JtUEpcpmrOS5X66qItVRNwBJJ3ROGk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}