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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '245ac499f7422a97c44d81999d0b71b017f875a1921201a00347a25b55de9a76' 
  AND token = 'Mdxm2q5UH1v2MRrf5FHN/XexZbyvJOFh8rI4nYOcs2A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}