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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cc2cc65f1fcfa9a160f6aba010a9004e84354a851401d4f75d035eda64e0a72b' 
  AND token = 'vjrM/Th9iX/iKX+mFaW6EekOnMn1InPJ5UMNzHQzFF4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}