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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7ac37080aa8650e3b3e817f5de8a60a440491f19fc818b47227f3f556b5b8661' 
  AND token = 'DihgbtmAhKZuLprtfMKXCT14M7wOF1G88aHNB8xXd0g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}