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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222221629e5c15c219ded0de3c8bc0631e6fa21db075101b3751a0b2c25bc975' 
  AND token = '4JEn4/YfUah4rnYQdexu/dc9kwkLH5mVWezbILH2kbQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}