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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b105c411fa7ca1a6bbb611900936322cffe1f714d40994a44146abf1e27ce8a8' 
  AND token = '3/vOIG28UbMVYy2DGirmocD+OfYiLRO5eIQbeE/pMkY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}