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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43d0eee79231888896c1c3d3f5de77553dd991258fc2e571fd245ae75a2b4212' 
  AND token = 'EWDoDXobP/a0+X0DKV/lb08gT0zU5hRLdtMMGW28MzA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}