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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '040dc116d467b2fb5d8486ce0476e72c6d0a0d935015bd5fc125abd66ef2845f' 
  AND token = 'EG6GCDJ2uzk+HHtvml8g6iyrwMxF1VlA2RZ61ZWCQ1A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}