SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '280ccca001bda94aea177617bfcbaf22ccaeb0b385dd80f1ee802abf86e64126' 
  AND token = '+Oig1Kqg+Svk8SJcTYgZpUzTVGjq7QiKt/evntnaZk4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00038

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}