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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8818fefe1b34e883093817fdc88d2d2bc461fa372cd8470fbe78dd240122b0e5' 
  AND token = 'y6I3Mgf//6/JrKfFWz4n/nv4MroG9+nX0npPx1Z6uMU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}