SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e0f3347a01185d28212ace9fb74ed7505d506f310455bceead2ac13072df7e73' 
  AND token = 'LT19TSq/5x7w/OQ/uZCQ6KWEVGGiM+HsKQ0bS8uudQw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}