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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65d1fe0a2da0539853b177e4741ed3218cb32355c9ca13cdf2ec2ba850838b3a' 
  AND token = 'QO4wHzbd8vWhq+bso+ACnTWi8kuVBNfUKAhL00IPlkg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}