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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '377b5b377fb641610d4273d5f13efca37e033494bf4eaeace7e122ef408b66f6' 
  AND token = 'F0N5pxJ10ugMc/3v7fLgWcB+9bZJTs+UbhmZ25DVL9s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}