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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10bcd109fc2cf0805dbb4d48bddabdd63c83a457deefd3405666aedca530cf06' 
  AND token = 'K46MH5J7FWrumVWWNhvqGD5vZgW5uJi4H3q4Ma0rbzM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}