SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f22744c2bfb3895e274057e6fb0344ea5f9cea55140d848bf7f042b74973f651' 
  AND token = 'TFgnmrrzs2sVtoVhqoFZTQI62FB9jHAGwbsP0KYDmSM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}