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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8a753c646518a80001dc132a3c3c6ea303ad90ba6d7baadebf6dc5721371fd5' 
  AND token = '+nF0lnguptucQxrUnczctBCZPIzKm5dIsjYx3yQ5DdQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}