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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c888ce6d07b20f3e1303bd19a66102dd7fc4784a0ed80bb33ab0acaa4acf02bc' 
  AND token = 'ZwehnADEZemoRkA5zeDCh0khfyf5oftU7tg3u0MDWpg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}