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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f21b41e8d724147246605a8f3d8e8be276de6540b5cb43ea3d1f892a71f05763' 
  AND token = 'lbWyLZ+oT/+tzyxGV8Y6aCLzsuNxAs1S7gxMeu/+KvA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}