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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4acb08730bb02d7f25947e38468390a1ce8f03d7260331b4cfc7c24650296280' 
  AND token = '8CTgxD/NS4SqcrdKFj/WNIAQimT6ltA6eAaJnnkmsKE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}