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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46360f43d70ec2dab30e807285e5348378dcf6d27c287c5b5c3c62661d9b91c9' 
  AND token = 'kFMrSMC/7hn/h4zi0bvP2KcmM5XQE8vseVOCFrz4L5Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}