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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ce8ea42cea3e6d4fcc721328b5b54784a50d000dabdc6cbded5b96a5b43b538' 
  AND token = 'dATQZAucsbLPts+W2CcZ/7S7x0+vzj6Y0nq9TRBXhFk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}