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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6376e4523aa57463a997eaabe6d4601ce08bb025c456240d7dfd9b26fa65bc05' 
  AND token = '+lIxTYkazCk9e6WBcW8w5lS7HIoZqVH7T4HIhepjT58=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}