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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '644c24f13852c59eeb6e60b4f4f5d61e52011a41d48871f6674586541d422b59' 
  AND token = 'f5YNTx13RT04a8dLOfCGZk6sxi/iDcWE8B8FqLWMzvg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}