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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5b6495029e1c47030d8bfecc4d9f7431136a4722512c3a8465b85e5a89eb7383' 
  AND token = 'MEP+vHj0QYYl7eUhmmOExBFNcwOQbsm0hU38jUocP3M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}