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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '456ccf374b6a1819113646bf8a64183cfdbc4d77b8b3d350bd8c7e02867dadfb' 
  AND token = 'kyCbC+zhfQKZP3xlmv4c1fooGE3OotvzxRzmBL1KCgg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}