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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e24df418ef1c1257c34a8f047255add4e775fdc5414fc5371dd1f99978ec535' 
  AND token = '49sMNVqWrSD55OVV4k/N29gOPtnjIiFNQ94WklZCPXk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}