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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '458d0f614028b094ff2e534cec491c5af7df9a047ccd7d376aebcd12fce4ae35' 
  AND token = 'dqU3bEZQGumbmQFE1Eq++F6H1w4qWrXXBQGm6/5wI1Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}