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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a4353217416ee37ba7d5024e015e66e2550a1ef2098e3b09b4264d5be4c0b1c' 
  AND token = 'w2ABZtzD67DJ5x9vRYFWw3CXfbcpBgtVOqdif4pikLA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00052

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}