SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '17ad4b4ede838ad775707cd63065270f02e812164f8bf438defd50b1ac076cf0' 
  AND token = '0XIU+sh/vnNCVSw+WWsarCSrZmfXYeRZ8HIR0Ad3Vjk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}