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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4546527cd1993511f8480d67a5abcff678a1a0e3992416299eb8ae15ddb37f11' 
  AND token = 'S9PzL4Qo+qCKuKBjXV3CaAPigxEbd6x1mWEsqgHSbPI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}