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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a45a4409e335f0ace1aeb290d784a5d6c70fd664b7fb7791568d5009e4e5e881' 
  AND token = 'wD9YAdAgjwSIk1UIbEkJHn9Pa3tRvFRVW7iuom8IJP4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}