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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45afbe532b0396017ea68fb6bc2358c61aed3dc746bed8bfe0b8d7366be516fb' 
  AND token = '8MQ8fM4GDRmazbjpCEDb5q3neWHlcDEQaLn5pwx6Xlo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}