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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43773de49a74c6970e2e249db7962c940cbf59f976cd2c97c98fb6aad73ec202' 
  AND token = 'gKvqA98tAzbChlaMPc6s6TMvNobMq26NcnaSdaFZWTc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}