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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '11a2b28cbd8eaddf2190a0519271baf1e4bc5178c0cde0280ba5532f23b1c225' 
  AND token = 'lj2Z0Cll/YpMZTEi3//oZzREJ4rKp9QBXNs1t7EKDbs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}