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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a461e877b221a603d1647315906e2d8c815f11193a365e9377eb6225f9ff1231' 
  AND token = 'x4AFw4Hvw2+ByAU1nhJQbCaYPqmMkNO3DS6HEjYXIEc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}