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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '424c85d8d40b20a40058cbdfc7e0c08eba97f6c508611b8a56b3a5bfc0eec134' 
  AND token = 'BkCTUtvTQ1/tpz4z/Gp0ZmydSyMjzJoTbpp86vBZbF8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}