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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22a9ee08413de3e4014125f507981b7be7d31c2334acd3612b291c1fd02adeaf' 
  AND token = '1uATUWRQJbBGXApsDW6JJwqfCKwByT70SC+LwC2cx3I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}