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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c187e8bf90e757137b41db804a9fff3b907016323aedc0c27ca185f8c2beb2cf' 
  AND token = 'GF43Moh//s3Nxe1LhUPusjqgqL/UUEq1gN13k3Deg1I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00049

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}