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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25ea2b38a7174e0b1dfe62944b349912bb00610cbb54cb8949daea77b4ed91eb' 
  AND token = 'ogWxPHwMpxdTwUfXChBgSlor0aTXxt2BcCVVQ3bGR4Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}