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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22a65a40a122200fc39d9cb4fd3d497f991d1110eabc9502082e8aab01f7bc50' 
  AND token = '+QCVVeXQzcu9D7UUAvTIyOr/qQ2uYeDV2y6v9lA23Yw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}