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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12889725b5e64ea6543c790773fdbdcd40b0b6495d3ec88ec89c9f0f220d2446' 
  AND token = 'ID6LUwRXKO2Y8UFfa3TJwYkWVW5eVlyAO4N6Rd68Zmc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}