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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b2072744aaace1164be4b85b84bed8b16ade51e8a5d0e74e1f652a8be6107224' 
  AND token = '/aQB7dMKdQV6z+bh/3ZLnYsTiUkmQ9C1hfq0OqBW3/0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}