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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72a744ce4bcc08e77682e8edce7dc41ce74a4ee6bc52d3d046e2e0b0e97da574' 
  AND token = '3dnHlO0mwkJc7+msr/RZH+tAhYEu7TPTyWnP3zoSpic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}