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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c346cd1e502bfbb1fc0289819e8d5e5b905e07657b2b8ffbed13a4379f577080' 
  AND token = 'uXP8GyZiUp8l+qBtc2rMNIdKMC3ueo2QmCG0qkmSUIM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}