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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25dc10dda9780303e18e18877f2b7d90d64bd7ccf0ecfce4a07fb4470652a74c' 
  AND token = 'eg+HAbtDRsE3MTABdHpGRyxlRd7bR/a4AZ3Ch0F8JJU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}