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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45543f95b212c6c2bd3fca0dfa2b6e3ce32c51133079c1433e06eb900c1becba' 
  AND token = 'Md+z505x3Nb1lONNHLJk5KAlmsYeBtlJ1ngc6PNNaoE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}