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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a53d8f35b4b385d0f8611e3cac6f3927dbbd6db037b5c3948e5702cfa3165305' 
  AND token = 'tANt4eA4Sot4T4sVRHA1sBqA4HXhebSWhW+RUa5kzws=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}