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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4f40f4de725d18d45e75d1b75d24e6f657a298cf4f669c429aeadafd25348f6b' 
  AND token = 'vFmLfrTo+f5eo1c80b1EuOOCZ/mQs+50v2mwxMUpzKc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}