SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22655829d1717c9449715e0014f1bd3aa69d58a13fe7e3e24826c91b42a1aa89' 
  AND token = 'XatGv3/sUrF17ofpDf1/Ut6SyIaYeM7XEWJiQaYVtEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}